Annals of Disaster Medicine

ISSN:1684-193X

Abstract ---Botulism, a potential lethal disease related to neurologic complications caused by neurotoxins most of then were produced by Clostridium botulinum. Food related botulism, infant botulism and wound botulism were reported all over the world after the first published by Kerner in 1820, botulism of adult with unknown was distributed in recent year which may due to colonization in gastrointestinal tract or toxin produced in vitro. The botulinal neurotoxin is the most lethal biological substance known, and it can be purified in laboratory. Bioterrorism is discussed after the terrier attack of United State in 2001 and botulism is one of the most possible agents. Prevention to the attack of biological weapons is impossible, it is emergent that clinicians should learn to recognize, diagnose and manage this rare but lethal disease, include the possibility of large outbreak due to terrorism.