電子期刊                   

電子期刊

ISSN:1684-193X

Updated October 18 , 2004

Contents:
Volume 3, Supplement 1; October, 2004
Wild Animal Injury in Taiwan
Yu-Ching Chen, MD; Tzong-Luen Wang, MD, PhD

 

From the Department of Emergency Medicine (Chen YC, Wang TL), Shin-Kong Wu Ho-Su Memorial Hospital

Correspondence to Dr. Tzogn-Luen Wang, Department of Emergency Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Taipei, Taiwan. E-mail M002183@ms.skh.org.tw

 

Abstract

 
Top
Abstract
Introduction
Antimicrobial Therapy

Conclusion
Referemces
Taiwan's varied landforms contribute to its abundant wild life species. Despite the decreasing number of wild animals caused by the cultivation of forest zone and over hunting on the island, cases of wild animal bite are still reported each year. The focus of care for these cases includes wound care, tetanus immunization, and human-animal communicable diseases prevention and treatment. It is also an important part of wildness medicine. Along with the frequent interactions among Taiwan and other rabies epidemic areas and the rampant smuggling of wild animal in black market, the threat of rabies needs to be critically considered and recognized in Taiwan.
Key words---Wild Animal Injury; Wild Animal Bite; Rabies

 

Introduction

 

Due to the varied landforms and the subtropical climate, there are 64 species of mammals in Taiwan (Figure) (Table 1).1,2 Although the number of some wild animal has decreased due to the development of circumstances and hunting, sporadic animal injury events are reported every year.
Wild animal injuries include bites or claw wounds from a wild animal, the crush injuries caused by large animals and the diseases transmitted by wild animals through wounds or by close contact. Due to the limited species of large mammalian animals including the Formosan black bear, boar , and wild deer in Taiwan, and the decreasing number of these species caused by unrestricted hunting and cultivation of land, and the environmental change of their natural habitat, only very few cases of large animal injury are reported in Taiwan every year. The more commonly seen cases are biting wounds caused by smaller mammalian animals such as Formosan macaques.
The most concern of animal bite transmitted diseases is Rabies worldwide. No rabies case has been reported in Taiwan since 1959. However, due to the frequent interflow and smuggling with Mainland China and other countries with rabies-epidemic, rabies is becoming an emerging problem. A rabies case was identified in Taiwan and reported in July, 2002. As reported, the victim was first bitten by a dog in Mainland China, then starting feeling ill and eventually died in Taiwan.3 As evidenced, Taiwan is affected and threatened by rabies. In addition to rabies, other important and ever-reported diseases transmitted by animal injury in Taiwan also include: Tetanus infection, rat-bite fever and cat scratch fever.


Top
Abstract
Introduction
Antimicrobial Therapy

Conclusion
Referemces

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Figure. Distribution of mammals in Taiwan
 
Table 1. Wild mammal species in Taiwan
 
Mammalian Bite Wound and Mauling  
   
The biting wounds caused by wild mammalian can be various. The severity of wounds may span from a simple scratch to more severe punctures, lacerations or avulsions . All can result in significant damage, regardless of the amount of bleeding present. Larger mammalians are able to deliver a bite force of greater than 450 pounds per square inch,4-6 capable of perforating light sheet metal.(Table 2) This type of crush injury is common and may result in tearing and tissue devitalization, which enhances the risk for infection. Lacerations or, less commonly, puncture wounds and avulsions may also occur. Among the various wound types, puncture wounds are touted to have the highest incidence of infection, whereas injuries involving the hand or joint carry the greatest risk of infection and disfigurement. Other potential complications that should be considered include osteomyelitis, septic arthritis, tenosynovitis, local abscesses and, rarely, endocarditis, meningitis, brain abscess and sepsis.7
 
Table 2. Wild mammal species in Taiwan
 
   
Complications of Bites
 
The most common complication of bite is infection. Bleeding is another common complication especially when there are vessel injuries. Mammalian teeth may result in a deep laceration, thus creating a route for microorganisms transmission. Osteomyelitis, septic arthritis, tendinitis or tenosynovitis may be seen with tooth penetration into a bone or joint8. Bites of the cranium may yield central nervous system infections such as brain abscess.9 Endocarditis, lymphangitis, meningitis and sepsis with disseminated intravascular coagulation have also been reported. Other infectious complications of mammalian bites include cat-scratch disease (Afipia felis), rat-bite fever (Streptobacillus moniliformis), rabies, tularemia (Francisca tularensis) and tetanus.10
 
 
Treatment  
   
Emergency care should be sought immediately if there are serious injuries, the person is suffering from severe blood loss, significant flesh loss, or there are many bites. It is also important to seek emergency care if the person has been bitten by a strange animal.
   
Wound Management  
   

1. Open wounds should be irrigated with copious volumes of normal saline as soon as possible. The preferred way is to use high pressure irrigation with normal saline or lactated ringers via a 19 gauge needle and large syringe.
2. The police should be notified of the incident.
3. When possible, tetanus toxoid and rabies vaccination status should be determined for all animal bites. (The rabies vaccination is not recommended in Taiwan)
4. Assess the extent of damage to the tissues including joint involvement, consider a roentgenogram to rule out a fracture if suspected, determine the need for cosmetic repair, stratify the patient for risk factors of infection, obtain wound cultures if infection is suspected (i.e. fever, erythema at injury sites, and observe necrosis or purulent wound drainage).11 (Table 3)

 
Table 3. Evaluation and care f bite wound
 
Microbiology  
   

Infections caused by animal bites are often polymicrobial, with an average of three to five bacterial species isolated per wound culture.
Staphylococcus spp., Streptococcus spp., Corynebacterium and various gram-negative enteric pathogens are the most commonly identified aerobes. Bacteroides spp., Fusobacterium, Peptostreptococcus, Actinomyces, Veillonella parvula and Eubacterium are commonly identified anaerobic organisms (11)

 
 
Top
Abstract
Introduction
Antimicrobial Therapy

Conclusion
Referemces
Antimicrobial Therapy
 
Prophylactic treatment

It has been suggested that antibiotic serum concentrations should be therapeutic within 3 hours after the injury. The recommended duration of prophylactic therapy with oral agents is a period of 5-7 days.
Those with more severe wounds, diabetes, vascular disorders, or who are immunocompromised may require a more aggressive approach with oral or parenteral antibiotics. The selection of an antibiotic regimen should follow the same criteria of empiric therapy of an infected bite wound.

 
Empiric antibiotic therapy of infected wounds

An appropriate empiric antibiotic regimen must direct at the pathogens most likely to cause infection, including both aerobic and anaerobic bacteria. Therapy should target organisms from both the oral cavity of the animal, as well as potential pathogens from the skin flora of the victim.
Indications for hospital admission include signs of sepsis, fever, significant edema or crush injuries, spreading cellulitis, involvement of a bone, joint, tendon or nerve, failed outpatient therapy, and immunocompromised hosts. Intravenous therapy may also be necessary in patients with known histories of medication non-compliance.
The most common agent for mammalian bites is monotherapy with amoxicillin/clavulanate owing to the additional anaerobic coverage offered by the [beta]-lactamase inhibitor. Alternative regimens include clindamycin plus ciprofloxacin, dicloxacillin plus penicillin, tetracyclines, trimethoprim/sulfamethoxazole, and second- or third-generation cephalosporins such as cefuroxime.11 (Table 4)

Table 4. Selected antibiotic regimens for therapy of bite wounds
 
Rabies  

Several countries, most of which are islands, are rabies free, including the British Isles, New Zealand, Japan, Taiwan, many of the Caribbean islands, Sweden, Norway, and Spain. The fact that these countries remain free of rabies is a tribute to the stringency of their quarantine laws for imported animals. Australia was at one time believed to be rabies free, but bat-transmitted rabies is now endemic there.
Although no rabies case was identified in Taiwan since 1959, due to close interactions and black market animal smuggling among Taiwan and other rabies plagued countries, the diagnosis of rabies should considered while a history of animal bites is presented. At present, rabies vaccine is not required for human as a preventive measure when biting by animasl in Taiwan. Even a rabies case was identified in 2002 in HuaLiang , the bite took place by a dog in Mainland China instead of Taiwan. Furthermore rabies is not yet detected among local wild species in Taiwan for the time being. However, preventive rabies vaccine is required by the Council of Agriculture for all domestic animals in order to prevent the spread of the disease through animal smuggling from nearby rabies epidemic areas.
Rabies is a fatal viral encephalitis that causes 30,000 to 70,000 deaths worldwide each year. Prevention is the primary approach to the disease. Rabies is transmitted usually by saliva from infected animal bites. However, recent findings that rabies can be transmitted from bats to humans by relatively casual contact have resulted in dramatic changes in guidelines from the Centers for Disease Control and Prevention for postexposure prophylaxis.

 
 
Pathogenesis  
   
Rabies is caused by a bullet-shaped RNA rhabdovirus that is a member of the Rhabdoviridae family, genus Lyssavirus. Rabies is transmitted by saliva from infected animal bites but may also be transmitted by scratches, secretions that contaminate mucus membranes, aerosolized virus that enters the respiratory tract, and corneal transplants. In recent years, it was noted that rabies could be transmitted from bats to humans by relatively casual contact. The rabies virus has a predilection for nerve tissue and spreads along peripheral nerves and possibly muscle fibers from the contact site to the central nervous system (CNS), causing encephalomyelitis.
 
   
Clinical Features  
   
Rabies is a fatal disease once clinical symptoms manifest. Only 6 documented cases survived after onset of clinical rabies. All these patients had received either preexposure prophylaxis or expeditious postexposure prophylaxis after the rabid contact and before the patients had established clinical disease. Rabies presents with 1 of 2 clinical features. Encephalitic (furious) rabies (80%-85% of cases) has the classic presentation with hydrophobia, pharyngeal spasms, and hyperactivity leading to paralysis, coma, and death. The paralytic form is much less common. Incubation periods range from 10 days to 1 year (average, 20-60 days). Prodrome occurs 2 to 10 days after exposure and lasts 1 day to 2 weeks. This stage is characterized by nonspecific flu-like symptoms such as malaise, anorexia, irritability, low-grade fever, headache, nausea, vomiting; paresthesia, pain, or numbness at the bite site.
Acute neurologic syndrome occur 2 to 7 days after the prodromes. This syndrome includes dysarthria, dysphagia, excessive salivation, diplopia, vertigo, nystagmus, restlessness, agitation, visual or auditory hallucinations, manic behavior alternating with lethargy, hydrophobia secondary to painful contractions of pharyngeal muscles, polyneuritis; hyperactive deep tendon reflexes with positive Babinski signs and nuchal rigidity often are present.
Coma occurs 7 to 10 days after onset of acute neurologic syndrome. This stage is characterized by hydrophobia, prolonged apnea, and generalized flaccid paralysis similar to Guillain-Barre syndrome, seizures, coma, and ultimate respiratory and vascular collapse. Death may follow 2 to 3 days after onset of paralysis but may be delayed by life-support equipments. Recovery is rare.
Unfortunately, once the patient is symptomatic, use of antirabies vaccine or rabies immune globulin (RIG) does not improve prognosis, and treatment consists entirely of supportive care.
   
Animal Reservoirs
 
Domestic animals that transmit rabies (dogs, cats, cattle) account for only 10% of human exposures, whereas wild animals account for the other 90%, with skunks, foxes, raccoons, and bats being the most prominent. Dogs are the primary reservoir in undeveloped countries.
 
Prevention
 

Rabies cannot be treated. Therefore, efforts must focuse on prevention.
1. Rabies immunization for domestic animals
2. Education about avoiding contact with wild animals is an important public health issue on reducing risk of rabies exposure. Raccoons, skunks, foxes, and coyotes can be enjoyed from a distance, but they should not be attracted intentionally or adopted.

   
Pre-exposure Prophylaxis
 
Pre-exposure prophylactic immunization is recommended for people who are likely exposed to rabid animals. Veterinarians, animal handlers, and laboratory personnel should consider routine immunization. Also, people traveling to areas where dog rabies is endemic and who will not have easy access to medical care should consider immunization before traveling. A person who was previously immunized and who has had a potential rabies exposure should receive 2 intramuscular doses of vaccine. Give the first dose as soon as possible after exposure and the other 3 days later.
 
Post-exposure Treatment
 

Passive Vaccination---RIG is a solution of globulins dried from the plasma or serum of selected adult human donors who have been immunized with rabies vaccine and have developed high titers of rabies antibody.
RIG is administered to previously unimmunized people so that passive antibodies are present until the person begins making active antibodies to the vaccine. RIG should not be given more than 7 days after initiation of the vaccine because RIG may decrease a person's own antibody response. RIG is given in a single dose of 20 IU/kg body weight. After the initial vaccine is given, the 4 subsequent doses should be given on days 3, 7, 14, and 28. The production of specific antibodies against rabies virus requires about 7 to 10 days to develop.
Active Vaccination---Three rabies vaccines are currently available in the United States: rabies vaccine adsorbed, human diploid cell rabies vaccine, and purified chick embryo cell vaccine; all 3 are inactivated virus vaccines.
Patients who are taking corticosteroids or are immunosuppressed may not develop active immunity with the vaccine. Antibody titers may need to be monitored.
No evidence has shown that RIG or the rabies vaccine causes fetal abnormalities. Therefore, pregnancy is not a contraindication to appropriate rabies prophylaxis. RIG and the rabies vaccine have been used without problems in infants.13, 14, 15(Table 5)

Table 5. Indication for rabies immunization
Tetanus
 
The highest incidence rate of such disease in Taiwan took place in 1956 with the number of one thousand and four identified cases. Ever since the beginning of toxoid vaccination in 1972, the case number has gradually decreased to less than 100 cases. Since 1981, the number of annual reported Tetanus cases has been maintained under 20 cases per year, and the mortality rate has also decreased to single digit number (several cases).
 
Epidemiology
 
Approximately, 50% of cases of tetanus in the United States occur after injuries. Infected wounds (both traumatic and surgical) and abscesses, surgical wounds, parenteral drug abuse, major trauma, and animal-related injuries account for 25% of the tetanus-associated injuries. Because immunization is effective in preventing tetanus, the disease is most frequently noted in countries or in ethnic groups whose effective immunization is less likely to be accomplished.
 
Etiology and Pathophysiology
 

The tetanus bacillus is a Gram-positive, anaerobic rod that may develop a terminal spore, giving it a drumstick appearance. They can survive in soil for years and may be found in house dust, soil, salt, fresh water, and the feces of many animal species.
After into tissues, spores convert to vegetative forms, multiply, and elaborate tetanospasmin. Tetanospasmin enters the peripheral nerve at the site of entry and travels to the central nervous system (CNS) through the nerves or is transferred by the lymphocytes to the CNS. The toxin binds to gangliosides at the presynaptic nerve ending in the neuronal membrane, prevents release of neurotransmitters, and affects polarization of postsynaptic membranes in complex polysynaptic reflexes. The lack of inhibitory impulses that results is manifested in the characteristic spasms, seizures, and sympathetic overactivity of tetanus. The toxin has no effect on the mental status, so consciousness is not impaired directly by this illness.
The length and the course of the illness are determined by the location and amount of the bound toxin. The complete course of tetanus takes usually from 2 to 4 weeks and is in fluenced by patient age and the development of complications.

 
Clinical Manifestation
 
In addition to neonatal tetanus, tetanus can present in 1 of 3 clinical forms: localized, generalized, or cephalic. We just introduce generalized tetanus here:
Generalized tetanus

It is the most common form of clinical tetanus. It may occur after relatively minor injuries and often follows tetanus-prone wounds. The typical initial findings of trismus due to spasm of the parapharyngeal and masseter muscles are seen in 50% of cases.
Common complaints are pain, swallowing difficulty, and unilateral or bilateral stiffness of the neck and other muscle groups, such as those of the abdomen or thorax.17 Persistent trismus accounts for the risus sardonicus that is considered a classic finding of tetanus. As the illness progress, additional muscle groups become involved. One of the most striking findings occurs with spasm of the paraspinal musculature, which may result in severe opisthotonos. All voluntary muscles can be affected and the disease may involve the larynx, which can be fatal. Minor stimuli including light, drafts, noises or voices, and light touch may trigger spasms.
The effect of tetanospasmin on the autonomic nervous system can induce cardiovascular instability. Labile hypertension and episodes of tachycardia or other tachyarrhythmias are common. The sympathetic overactivity or superinfections, such as pneumonia can cause fever. Spasms and cardiovascular complications occur most commonly during the first week and resolve slowly during the ensuing 2 to 4 weeks.

Complications
 
Complications of tetanus include direct toxic effect (laryngeal and phrenic nerves palsy, and cardiomyopathy), and spasm-related sequels (respiratory compromise, rhabdomyolysis, myositis ossificans circumscripta, and vertebral compressed fracture), respiratory compromise (hypoxic cerebral injury), and rhabdomyolysis (acute renal failure), as well as the psychologic impact.
 
Diagnosis and Differential Diagnosis
 

The classic presenting complaints in tetanus consist of muscle spasms, trismus, stiffness, pain with dysphagia and cranial nerve weakness. These can be seen in other conditions.
The lack of altered consciousness in tetanus is an important point of differentiation from CNS infections, and a parapharyngeal inflammation can be diagnosed by clinical examination and/or radiographs of the airway.
Specific diagnosis of tetanus by routine laboratory tests is difficult. Gram stains and anaerobic cultures of wounds reveal the characteristic Gram-positive bacilli with terminal spores in as many as one third of tetanus patients. Although a positive wound culture can support the clinical diagnosis, a positive culture in the absence of symptoms does not indicate that tetanus intoxication will develop.

 
Diagnosis and Differential Diagnosis  
   
Appropriate treatment based on the clinical diagnosis is warranted even without specific confirmatory laboratory tests. The goals of therapy are eradicating C. tetani, neutralizing its toxin, and providing appropriate supportive care. Specific therapy includes intramuscular administration of tetanus immune globulin (TIG) to neutralize circulating toxin before it binds to neuronal cell membranes. Early administration of antitoxin may prevent spread of the toxin within the CNS. The recommended dosage of TIG ranges from 500 to 3000 U. Additionally, specific therapy includes antimicrobial agents for C. tetani such as penicillin G administered as 200,000 U/kg/d in 4 divided intravenous doses for 10 days. Alternatives for those allergic to penicillin include oral tetracycline (40 mg/kg/d; maximum of 2 g) or intravenous vancomycin (30–40 mg/kg/d).
Local wound care, including surgical debridement, is essential. Foreign bodies should be removed and wounds irrigated well and left open.
Patients should be managed in an intensive care setting of a tertiary-care center whenever possible. Facilities and equipments should be available including a quiet darkened room, suction equipment and oxygen, cardiac and respiratory monitors, a ventilator, and tracheostomy equipment. Neuromuscular blockade can be achieved with curariform drugs. The agents used most often are pancuronium and vecuronium.
The hypertension that results from sympathetic overactivity may require treatment. Beta-blocking agents are the most useful. Propranolol is administered most commonly.


Maintaining adequate nutrition and hydration is of outmost importance. Parenteral nutrition is usually required because of the likely length of the disease and the undesirability of oral or nasogastric feedings. Tracheostomy may be required to prevent laryngospasm.

 
   
Mortality  
   

The worldwide mortality rate for generalized tetanus ranges from 45% to 55%. Although survivors generally do not experience neurologic sequelae, prolong convalescence with residual muscle rigidity is seen for several months.
The main predictors of prognosis are the rapidity of symptom onset and the rate of progression from trismus to severe spasms. Poor outcome is predicted by an interval between injury and trismus shorter than 7 days.

 
   
Prevention  
   
Active immunization with tetanus toxoid is the most effective mean of protection. The primary series of tetanus toxoid, administered as DTP vaccine at 2, 4, and 6 months and a booster 12 months later, ensures protection in childhood. Additional boosters of tetanus toxoid should be given each decade throughout life.18  
   
Rat-Bite Fever  
   
Rat bite fever is a systemic illness classically characterized by abrupt onset of fever, rash, and arthralgias, which carries a mortality rate of 13% if left untreated.  
   
Epidemiology  
   

In Asia the causative organism is usually Spirillum minus, a small, spiral gram-negative organism. Children account for more than 50% of rat bite fever cases. In the United States rat bite fever is caused primarily by transmission of Streptobacillus moniliformis, a pleomorphic gram-negative rod .
Rat bite fever can be divided into 3 clinical syndromes. 1. Rat bite fever caused by Streptobacillus moniliformis infection, which is the predominant form seen in the United States. 2. “Soduku” caused by Spirillum minus, seen primarily in Asia. 3. When the clinical syndrome follows S moniliformis ingestion via contaminated food it is called “Haverhill fever. “

 
   
Clinical Manifestations  
   
Rat bite fever is a systemic illness characterized by abrupt onset of fever and chills.  
   
Clinical Manifestations  
   
Fevers begin abruptly and usually resolve in 3 to 5 days but can relapse. The rash occurs in roughly 75% of patients and may be maculopapular, petechial, or purpuric. Hemorrhagic pustules or vesicles may also be seen. These usually appear 2 to 4 days after the fever resolves and may last up to 3 weeks. These often involve the extremities, especially the hands and feet. Approximately 20% of rashes due to S. moniliformis will desquamate. Other commonly associated symptoms include severe myalgias, headache, nausea, and vomiting. Within the first week, more than 50% of patients develop a non-suppurative polyarticular or migratory polyarthritis. The joint involvement may affect either large joints or the small joints of the hands and feet. Migratory arthritis may persist for years despite appropriate treatment.
 
   
Spirillum Minus  
   
The incubation period averages 14 to 18 days, with a range of 1 to 36 days. If there is a bite, infection is usually heralded by an indurated lesion at the site as symptoms become obvious. The lesions may ulcerate and there may be regional lymphadenopathy. The fevers have regular relapses separated by afebrile periods lasting 3 to 7 days. Approximately 50% of patients develop a violaceous red-brown rash that usually consists of large macules with occasional erythematous plaques or urticarial-type lesions. The joint manifestations are rare. The mortality with S minus infection is slightly lower than that seen with S moniliformis and approaches 6.5%.
If infection with either organism goes unrecognized, there can be serious sequelae, including arthritis, endocarditis, myocarditis, pericarditis, pericardial effusion, hepatitis, nephritis, and meningitis.

 
   
Diagnosis  
   
Blood culture isolation is the gold standard.  
   
Treatment  
   
Penicillin is the treatment of choice despite rare reports of penicillin-resistant strains. Current recommended treatment is 5 to 7 days of intravenous penicillin at doses of 20,000 to 50,000 units/kg/day followed by 7 days of oral penicillin.19
 
Top
Abstract
Introduction
Antimicrobial Therapy

Conclusion
Referemces
Conclusion
 
As we protect wild-animal species and acknowledge their right to share territory, interactions—and possibly attacks—are likely to increase. Awareness, education, knowledge and prevention, rather than the elimination of animal populations, may be the best way to control wild-animal attacks on humans in the future.
 
References  
 
Top
Abstract
Introduction
Antimicrobial Therapy

Conclusion
Referemces
1.
李培芬、林曜松。臺灣地區國家公園動物生態資料庫報告。內政部營建署,1994,台北
2. 李培芬、戴永禔、林曜松。臺灣野生動物資源之多媒體資料庫系統。臺灣動物資源資料庫建立研討會論文集(吳金洌、陳章波主編),1992,台北。
3. 東森新聞報。花蓮發現40年來首例境外移入---狂犬病人體病例 2002/07/12 21:15
4. Lewis KT, Stiles M. Management of cat and dog bites. Am Fam Physician 1995;52:479-85
5. Lewis KT, Stiles M. Management of cat and dog bites. Am Fam Physician 1995;52:479-85
6. Garcia VF. Animal bites and pasturella infections. Pediatr Rev 1997;18:127-30
7. Goldstein EJC, Citron DM, Finegold SM. Dog bite wounds and infection: a prospective clinical study. Ann Emerg Med 1980; 9:508-512
8. Brogan TV, Bratton SL, Dowd MD, Hegenbarth MA. Severe dog bites in children. Pediatrics 1995;96:947-950
9. Agahbabian RV, Conte JE. Mammalian bite wounds. Ann Emerg Med 1980;9:79-82.
10. Goldstein EJC. Bite wounds and infection. Clin Infect Dis 1992;14:633-640
11. Smith PF. Treating mammalian biting wound, Journal of clinical Pharmacy and Therapeutics. 2000;25:85-99
12. Hankins DG. Rosekrans JA. Overview, prevention, and treatment of rabies Majo Clin Proceedings 2004;79: 671-76
13. Weir E. Putting the bite on rabies. CMAJ 2002;167:781
14. Jackson AC. Update on rabies. Curr Opin Neurol 2002;15:327-31
15.. Kaeser HE, Sauer A. Tetanus toxin: a neuromuscular blocking agent. Nature 1969;223:842
16. Einstein L. Tetanus. N Engl J Med. 1973;289:293–96
17. Itzhak B. Tetanus in children. Ped Emerg Care 2004;20,48-51
18. Freels LK, Elliott SP. Rat bite fever: three case reports and a literature review. Clin Ped 2004;43:291-5
19.. Norwood.S. Mechanisms and Patterns of Injuries Related to Large Animals. J Trauma 2000;48:740-744
   

 

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